Developing novel theory and methods for understanding the genetic architecture of complex human traits (R01 Clinical Trial Not Allowed)
Department of Health and Human Services — National Institutes of Health
- Program summary
- The goal of this NOFO is to support applications for novel theory and methods development that enable better understanding of how genetic and non-genetic factors contribute to complex trait variation across individuals, families, and populations. Approaches should be interdisciplinary drawing from the natural and social sciences, account for interdependencies across scales of biological, social, and ecological organization, and make extensive use of theory, modeling, and validation with available large-scale datasets.
- Eligibility as stated by the source
- Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
- How to apply
- Apply through Grants.gov
- Contact
- National Institutes of Health · grantsinfo@nih.gov · 301-402-2541
- Notes
- Opportunity number PAR-25-255.
Before you can apply
Federal applications require an active SAM.gov entity registration (Unique Entity ID) and a Grants.gov account with an Authorized Organization Representative role. SAM.gov registration commonly takes 2 to 4 weeks, so start it well before the deadline.
- SAM.gov entity registration (UEI) — typically Commonly 2 to 4 weeks · No feeFederal grant and contract applicants must hold an active registration in the System for Award Management, which issues the Unique Entity ID used on every federal application.Start this registration
- Grants.gov account and role assignment — typically Commonly a few days after SAM.gov registration is active · No feeApplications submitted through Grants.gov require an individual account plus an Authorized Organization Representative role approved by your organization's e-Business Point of Contact.Start this registration
- Employer Identification Number (EIN) — typically Same day when applied for online · No feeAn EIN identifies the applying business or organization on nearly every funding application.Start this registration
- IRS tax-exempt determination letter — typically Varies; already issued for established nonprofits · Application fee applies to new filingsNonprofit-restricted programs generally require a copy of the IRS determination letter recognizing tax-exempt status.Start this registration
Source and verification
- Primary source: http://grants.nih.gov/grants/guide/pa-files/PAR-25-255.html
- Source reference ID: 357135
- Some categories on this record were inferred from the program text rather than stated explicitly by the source.
Change history
- Sep 30, 2026 — Discovered: open